专家简介
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侯天勇
性别:男
研究方向:脊柱外科,骨修复材料及成骨机制
周一
诊室三
职称:副主任医师/副教授
擅长:脊柱退行性疾病的通道下微创治疗、脊柱退行性疾病、腰椎管狭窄症、腰椎间盘突出症、腰椎滑脱症
学历:研究生
专业:脊柱外科
毕业院校:第三军医大学
教育经历
1997.09-2002.07原第三军医大学本科学员
2002.09-2005.07原第三军医大学硕士研究生
2005.09-2008.07原第三军医大学博士研究生
工作经历
2008.06原第三军医大学第一附属医院骨科讲师、主治医师
2017.12陆军军医大学第一附属医院骨科副主任医师、副教授
2018.12陆军军医大学第一附属医院骨科主任助理
学术职务
中华医学会骨科学分会创新与转化学组青委会副组长
中国生物医学工程学会组织工程与再生医学分会 委员
重庆市医学会骨质疏松及骨矿盐疾病专业委员会委员
表彰奖励
2008年获得《军队科技进步一等奖》 , 获奖理由:抗感染组织工程骨的研究与应用
2009年获得《重庆市优秀博士论文》 , 获奖理由:复合万古霉素缓释微球的组织工程骨的制备及其修复股骨缺损
2012年获得《学校临床技术创新一级乙等》 , 获奖理由:腰椎前路多向锁定钉板的研发与临床应用
2015年获得《学校临床技术创新一级甲等》 , 获奖理由:膜诱导技术结合生物活性骨修复材料治疗感染性骨不连骨缺损
2016年获得《军队科技进步一等奖》 , 获奖理由:战创伤高生物活性骨修复材料关键技术研究与产品开发
2017年获得《科技进步二等奖》 , 获奖理由:高活性组织工程骨关键技术、产品研发与临床应用
学术论文
1、Hou T, Xu J, Wu X, Xie Z, Luo F, Zhang Z, Zen L. Umbilical cord Wharton’s Jelly: a new potential cell source of mesenchymal stromal cells for bone tissue engineering. Tissue Eng Part A 2009; 15(9): 2325-2334. (IF 4.582)
2、Hou T, Li Q, Luo F, Xu J, Xie Z, Wu X, Zhu C. Controlled dynamization to enhance reconstruction capacity of tissue engineered bone in healing critically sized bone defects: An in vivo study in goats. Tissue Eng Part A 2010; 16(1): 201-212. (IF 4.636)
3、Li Q, Hou T (co-first author), Zhao J, Xu J. Vascular Endothelial Growth Factor Release from Alginate Microspheres Under Simulated Physiological Compressive Loading and the Effect on Human Vascular Endothelial Cells. Tissue Eng Part A. 2011,17(13-14):1777-85. (IF 4.022)
4、Hou T, Wu Y, Wang L, Liu Y, Zeng L, Li M, Long Z, Chen H, Li Y, Wang Z.Cellular Prostheses Fabricated with Motor Neurons Seeded in Self-Assembling Peptide Promotes Partial Functional Recovery After Spinal Cord Injury in Rats. Tissue Eng Part A. 2012,18 (9-10):974-985. (IF 4.065)
5、Xing J, Hou T (co-first author, co-corresponding author), Luobu B, Luo F, Chen Q, Li Z, Jin H, Xu J. Anti-Infection Tissue Engineering Construct Treating Osteomyelitis in Rabbit Tibia. Tissue Eng Part A. 2013;19(1-2):255-63. (IF 4.254)
6、Wu X, Hou T (co-first author, co-corresponding author), Luo F, Xing J, He Q, Jin H, Xie Z, Xu J.Vascular Endothelial Growth Factor and Physiological Compressive Loading Synergistically Promote Bone Formation of Tissue-Engineered Bone.Tissue Eng Part A. 2013;19(21-22):2486-94. (IF 4.254)
7、Chang Z, Hou T (co-first author, co-corresponding author), Wu X, Luo F, Xing J, Li Z, Chen Q, Yu B, Xu J, Xie Z. An Anti-Infection Tissue-Engineered Construct Delivering Vancomycin: its Evaluation in a Goat Model of Femur Defect. Int J Med Sci 2013; 10(12):1761-1770. (IF 2.061)
8、Hou T(co-corresponding author), Li Z, Luo F, Xie Z, Wu X, Xing J, Dong S, Xu J.A composite demineralized bone matrix - Self assembling peptide scaffold for enhancing cell and growth factor activity in bone marrow. Biomaterials. 2014;35(22):5689-99. (IF 8.312)
9、Xing J, Hou T(co-corresponding author), Jin H, Luo F, Change Z, Li Z, Xie Z, Xu J.Inflammatory Microenvironment Changes the Secretory Profile of Mesenchymal Stem Cells to Recruit Mesenchymal Stem Cells. Cell Physiol Biochem. 2014;33(4):905-919. (IF 3.550)
10、Chang Z, Hou T(co-first author, co-corresponding author), Xing J, Wu X, Jin H, Li Z, Deng M, Xie Z, Xu J.Umbilical Cord Wharton's Jelly Repeated Culture System: A New Device and Method for Obtaining Abundant Mesenchymal Stem Cells for Bone Tissue Engineering. PLoS One. 2014;9(10):e110764. (IF 3.534)
11、Xing J, Jin H, Hou T(co-first author, co-corresponding author), Chang Z, Luo F, Wang P, Li Z, Xie Z, Xu J.Establishment of a bilateral femoral large segmental bone defect mouse model potentially applicable to basic research in bone tissue engineering.J Surg Res. 2014; 192(2):454-63.
12、Chen Q, Hou T(co-corresponding author), Luo F, Wu X, Xie Z, Xu J. Involvement of Toll-Like Receptor 2 and Pro-Apoptotic Signaling Pathways in Bone Remodeling in Osteomyelitis. Cell Physiol Biochem 2014;34:1890-1900. (IF 3.550)
13、Hou T, Zhou Q, Dai F, Luo F, He Q, Zhang J, Xu J. Repeated microendoscopic discectomy for recurrent lumbar disk herniation.Clinics (Sao Paulo). 2015;70(2):120-5. (IF 1.185)
14、Li Z, Hou T(co-corresponding author), Deng M, Luo F, Wu X, Xing J, Chang Z, Xu J.The Osteogenetic Efficacy of Goat Bone Marrow-Enriched Self-Assembly Peptide/Demineralized Bone Matrix In Vitro and In Vivo. Tissue Eng Part A. 2015;21(7-8):1398-408. (IF 4.448)
15、Hou T, Wu Z, Xing J, Wu X, Luo F, Xie Z, Wang X, Xu J.Tissue-engineered bone treating simple bone cyst-a new strategy. J Surg Res. 2016;200(2):544-51. (IF 1.936)
16、Chen Q, Hou T(co-first author, co-corresponding author), Wu X, Luo F, Xie Z, Xu J. Knockdown of TNFR1 Suppresses Expression of TLR2 in the Cellular Response to Staphylococcus aureus Infection. Inflammation. 2016 Apr;39(2):798-806. (IF 2.208)
17、Yang A, Lu Y, Xing J, Li Z, Yin X, Dou C, Dong S, Luo F, Xie Z, Hou T(co-corresponding author), Xu J. IL-8 Enhances Therapeutic Effects of BMSCs on Bone Regeneration via CXCR2-Mediated PI3k/Akt Signaling Pathway. Cell Physiol Biochem. 2018;48(1):361-370. (IF 5.500)
18、Cui Y, Fu S, Hou T(co-corresponding author), Wu X. Endothelial Progenitor Cells Enhance the Migration and Osteoclastic Differentiation of Bone Marrow-Derived Macrophages in vitro and in a Mouse Femur Fracture Model through Talin-1.Cell Physiol Biochem. 2018 Aug 30;49(2):555-564. (IF 5.500)
19、Cui Y, Fu S, Sun D, Xing J, Hou T, Wu X.EPC-derived exosomes promote osteoclastogenesis through LncRNA-MALAT1.J Cell Mol Med. 2019 Jun;23(6):3843-3854. (PMID:31025509,DOI:10.1111/jcmm.14228)(IF 4.302)
20、Xing J, Lu Y, Cui Y, Zhu X, Luo F, Xie Z, Wu X, Deng M, Xu J, Hou T.A Standardized and Quality-Controllable Protocol of Constructing Individual Tissue-Engineered Grafts Applicable to Treating Large Bone Defects. Tissue Eng Part C Methods. 2019 Mar;25(3):137-147.(IF 3.508)
21、Lu Y, Xing J, Yin X, Zhu X, Yang A, Luo J, Gou J, Dong S, Xu J, Hou T. Bone Marrow-Derived CD44+ Cells Migrate to Tissue-Engineered Constructs via SDF-1/CXCR4-JNK Pathway and Aid Bone Repair. Stem Cells Int. 2019 Jul 24;2019:1513526. doi: 10.1155/2019/1513526. eCollection 2019.( IF=3.902)
专利授权
国家实用新型专利,肌腱粘连松解器, (专利号:ZL 201120374046.1)(排名第2)2012年5月30日年
国家实用新型专利,用于制备小鼠股骨骨缺损模型的固定装置, (专利号:ZL 201120374046.1)(排名第2)2011年
国家实用新型专利,构建高成骨活性骨的方法, (专利号:ZL 201610057023.5)(排名第1)2016年
国家实用新型专利,周期应力刺激型交锁髓内钉, (专利号:ZL 2006 2 0109987.1)(排名第1)2007年2月28日年
国家实用新型专利,手动细胞富集装置, (专利号:ZL 2010 2 0518067.1)(排名第1)2011年2月16日年
国家实用新型专利,螺钉可多向锁定固定装置, (专利号:ZL 2010 2 0518107.2)(排名第6)2011年4月20日年
国家发明专利,生物蛋白胶复合于富孔隙生物材料的负压灌注装置, (专利号:ZL 2013 2 0058080.7)(排名第1)2013年8月7日年
国家发明专利,脊柱结核脓液穿刺置管引流工具, (专利号:ZL 2013 2 0058091.5)(排名第4)2013年8月7日年
国家实用新型专利,含有脐带间充质干细胞分泌的多种蛋白的骨基质材料及制备方法, (专利号:ZL 201310449152.5)(排名第1)2014年12月17日年
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